2015, Cilt 24, Sayı 1, Sayfa(lar) 068-073
The Evaluation of Amyloidosis Cases with Renal Involvement: A Single-Center Experience
DOI 10.5262/tndt.2015.1001.09
Yavuz AYAR1, Alparslan ERSOY1, Abdülmecit YILDIZ2, Emel IŞIKTAŞ SAYILAR1, Sedat ÇELİKÇİ3, İsmail ARSLAN3, Mustafa Ferhat ÖKSÜZ4, Mustafa GÜLLÜLÜ2
1Uludağ Üniversitesi Tıp Fakültesi, Nefroloji Bilim Dalı, Bursa, Türkiye
2Bursa Çekirge Devlet Hastanesi, Nefroloji Kliniği, Bursa, Türkiye
3Uludağ Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Bursa, Türkiye
3Uludağ Üniversitesi Tıp Fakültesi, Romatoloji Bilim Dalı, Bursa, Türkiye
Keywords: Amyloidosis, Kidney biopsy, Proteinuria, Chronic kidney disease

OBJECTIVE: Amyloidosis is a chronic disease associated with proteinuria and can progress to renal failure. The diagnosis and treatment of the underlying cause is therefore important. In this study at a university hospital, the diagnosis of amyloidosis patients with renal biopsies was evaluated retrospectively.

MATERIAL and METHODS: 69 (42 males, 27 females, mean age: 51.7 ± 14.8 years) patients were diagnosed with amyloidosis with renal biopsy. Indications for biopsy was nephrotic syndrome in 42 patients (60.9%), nephritic syndrome in 27 (39.1%) and renal dysfunction with proteinuria in 31 (44.9%).

RESULTS: The most common causes of secondary amyloidosis were Familial Mediterranean Fever in 17 of the 62 patients, chronic inflammatory diseases in 17 patients and chronic infection in 13 patients. No cause was determined in 12 patients. Multiple myeloma was present in 5 patients with primary amyloidosis. At the time of diagnosis with amyloidosis, 19 patients were stage 1, 15 stage 2, 5 stage 3A, 12 stage 3B, 10 stage 4 and 8 stage 5. The baseline hemoglobin, serum albumin, creatinine, sodium, potassium, calcium, phosphorus, AST, ALT, PTH, SAA, CRP levels, average daily urinary protein excretion and baseline GFR values were not significantly different in primary and secondary amyloidosis patients. The treatment was medical in 62.3% of the patients, dialysis in 31.9% and renal transplantation in 5.8%.

CONCLUSION: The reliability of renal biopsy in the diagnosis of amyloidosis is high. However, genetic studies for the diagnosis of idiopathic cases and special histological staining methods should be considered.

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