2016, Cilt 25, Sayı 0, Sayfa(lar) 095-097
Hypothyroidism as an Obstacle to the Resolution of Acute Kidney Injury
DOI 10.5262/tndt.2016.20
Abdülmecit YILDIZ, Ayşegül ORUÇ, Bülent GÜL, Nimet AKTAŞ, Yavuz AYAR, Alparslan ERSOY, Mustafa GÜLLÜLÜ
Uludağ University Faculty of Medicine, Department of Nephrology, Bursa, Turkey
Keywords: Acute kidney injury, Hypothyroidism, Thyroid hormone replacement therapy

We described the clinical course of 4 patients with acute kidney injury (AKI) in whom kidney function improvement was delayed because of concomitant hypothyroidism. After initiating thyroid hormone replacement therapy, the kidney function improved partially or completely. We discussed the underlying possible pathophysiological mechanisms of delayed recovery. A 33-year-old female presented with kidney failure following severe preeclampsia. She was diagnosed with hypothyroidism. The second case was a 70-year-old male who was healthy previously, and presented with elevated serum creatinine. The third patient was a 72-year-old female, who was admitted with non-oliguric AKI associated with aminoglycoside and non-steroid anti-inflammatory drug exposure. The fourth patient was a 60-yearold female under amiodarone treatment after coronary bypass grafting who presented with fatigue, and AKI. We suggest that delayed recovery of kidney dysfunction might be associated with hypothyroidism that prevents regeneration of tubular cells.

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