2016, Cilt 25, Sayı 0, Sayfa(lar) 086-088
Everolimus-Associated Thrombotic Microangiopathy and Acute Kidney Injury in a Patient with Breast Cancer
DOI 10.5262/tndt.2016.17
1İzmir Tepecik Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, Nefroloji Bölümü, İzmir, Türkiye
2İzmir Tepecik Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, İzmir, Türkiye
Keywords: Everolimus, Thrombotic microangiopathy, Breast cancer

Thrombotic microangiopathy is a pathological condition caused by several factors including drugs, and characterized by endothelial injury and small vessel occlusion. It may cause severe acute kidney injury. Everolimus, a mammalian target of Rapamycin inhibitor, is a macrolide antibiotic widely used in clinical conditions because of its anticancer and immunosuppressive effects. Recently it has been approved for use in breast cancer at a dose of 10 mg/day in combination with exemestane, an aromatase inhibitor. In the literature a few cases of everolimus-induced thrombotic microangiopathy and acute kidney injury in breast cancer patients have been reported. Here we reported the management of a breast cancer patient with everolimus-induced thrombotic microangiopathy and severe acute kidney injury with emphasis on close monitoring of kidney functions.

Türk Nefroloji Derneği'nin yayın organıdır.