2017, Cilt 26, Sayı 2, Sayfa(lar) 140-146
Renal Stem Cells
DOI 10.5262/tndt.2017.1002.02
Egemen KAYA1, Özgür ŞENOL2, Sevgi MİR3
1Ege Üniversitesi Tıp Fakültesi, Fizyoloji Anabilim Dalı, İzmir, Türkiye
2Ege Üniversitesi Fen Bilimleri Enstitüsü, Biyoteknoloji Anabilim Dalı, İzmir, Türkiye
3Ege Üniversitesi Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları AD, Çocuk Nefroloji BD, İzmir, Türkiye
Keywords: Stem cells, Renal progenitor cells, Kidney regeneration

Kidney diseases, related to high morbidity and mortality, are one of the diseases that should be primarily investigated. Development of acute and chronic kidney diseases is due to lack of functioning renal repair mechanisms. Embryonic progenitor cells are precursors of renal cells that are able to differentiate to several types of nephron epithelium. Fetal renal progenitor cells are partially capable of self-renewal. In the adult human kidney, whole nephron regeneration is not possible. Progenitor-like cells continuously replace the cells that are lost physiologically or by damage. These cells have been differentiated to epithelial and endothelial cells in vitro. Transplantation of stem cells to the damaged kidney is one of the regenerative therapy options. In recent studies, it has been shown that chronic kidney disease, graft rejection and other kidney diseases could be treated and nephrons and other structures could be regenerated by stem cell therapy. Stem cells are the best candidates for the treatment of kidney diseases, organ transplantation and producing a functional organ. The success of this method is due to the ability of the cells to differentiate, to penetrate the existing tissue and the capacity of the cells to secrete renoprotective factors.

Türk Nefroloji Derneği'nin yayın organıdır.