2018, Cilt 27, Sayı 1, Sayfa(lar) 087-092
Thiol/Disulphide Homeostasis in Autosomal Dominant Polycystic Kidney Disease: A Single Center, Cross-Sectional Study
DOI 10.5262/tndt.2018.1001.07
Selin AKTÜRK ESEN1, Serdar KAHVECIOĞLU2, Yasemin ÜSTÜNDAĞ3, Salim NESELIOĞLU4, Emine Feyza YURT4, İrfan ESEN1, Ahmet HUNUK1
1Health Sciences University, Bursa Yuksek Ihtisas Research and Education Hospital, Department of İnternal Medicine, Bursa, Turkey
2Health Sciences University, Bursa Yuksek Ihtisas Research and Education Hospital, Department of Nephrology, Bursa, Turkey
3Health Sciences University, Bursa Yuksek Ihtisas Research and Education Hospital, Department of Clinical Chemistry, Bursa, Turkey
4Yildirim Beyazit University, Faculty of Medicine, Department of Biochemistry, Ankara, Turkey
Keywords: Oxidative stress, Autosomal dominant polycystic kidney disease, Thiol-disulphide, Creatinine

OBJECTIVE: The aim of this study was to determine a novel oxidative stress marker, plasma thioldisulphide homoeostasis, in patients with autosomal dominant polycystic kidney disease (APKD).

MATERIAL and METHODS: Thirty-four patients with autosomal dominant polycystic kidney disease and 30 healthy volunteers were included in the study. The thiol-disulfide homeostasis assay was performed. Total antioxidant capacity was evaluated via the FRAP assay.

RESULTS: The median age was 46 (13) years in the patient group and 41 (13) years in the control group. In the APKD disease group, serum total and native thiol levels were statistically significantly lower (p = 0.002, p = 0.002, respectively). Serum native thiol levels were negatively correlated with age (r:-0.620 p: 0,000), systolic blood pressure (r: -0,697 p: 0,000), and diastolic blood pressure (r: -0,643 p: 0,000). A weak positive correlation was found between the disulfide/native thiol ratio and creatinine (r: 0.564 p <0.001), and a negative correlation was found between the disulfide/native thiol ratio and glomerular filtration rate (r: -0.372 p: 0.030). There was a significant positive correlation between the native thiol level and GFR (r: 0.699, p <0.001) level.

CONCLUSION: Our findings suggest that thiol/disulfide homeostasis may be associated with autosomal dominant polycystic kidney disease progression.


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