2018, Cilt 27, Sayı 2, Sayfa(lar) 150-156
Significance of Apelin-13 for Inflammation and Cardiac Morphology in Peritoneal Dialysis Patients
DOI 10.5262/tndt.2018.2939
İbrahim DOĞAN1, Serdar KAHVECIOĞLU2, Barış ESER1, Hüseyin KAYADIBI3, Özlem YAYAR4, Tolga DOĞAN5, Ünal KURTOĞLU6, Sevda ÜNALLI ÖZMEN7, İsminur SAKA KARAGÖZ7
1Hitit University, Erol Olçok Training and Research Hospital, Department of Nephrology, Çorum, Turkey
2Bursa Yuksek Ihtisas Training and Research Hospital, Department of Nephrology, Bursa, Turkey
3Hitit University, Erol Olçok Training and Research Hospital, Department of Biochemistry, Çorum, Turkey
4Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Nephrology, Ankara, Turkey 5Hitit University, Erol Olçok Training and Research Hospital, Department of Cardiology, Çorum, Turkey
6Bursa Yuksek Ihtisas Training and Research Hospital, Department of Radiology, Bursa, Turkey
7Uludağ University Faculty of Medicine, Department of Biochemistry, Bursa, Turkey
Keywords: Apelin-13, Carotid intima media thickness, Inflammation, Peritoneal dialysis

OBJECTIVE: Apelin-13 is a biomarker that was shown to be related to cardiovascular disease risk in peritoneal dialysis patients. The aim of our study was to investigate the association of serum apelin-13 levels with inflammation, carotid artery intima media thickness (CIMT) and echocardiographic parameters in peritoneal dialysis patients.

MATERIAL and METHODS: 33 patient receiving peritoneal dialysis treatment (15 female) and 27 healthy controls (11 female) were enrolled. CIMT and echocardiographic measurements of all patients and controls were taken. Serum apelin-13 levels were measured by ELISA. Apelin-13, c-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), echocardiographic parameters and CIMT values were compared between patients and controls.

RESULTS: Apelin-13 was lower in the patient group [58 (12-131) ng/L] than in the control group [76 (18-130) ng/L] (p=0.083). CRP, NLR, CIMT were significantly higher in patients than controls (p<0.001). CIMT was 0.8 (0.4-1.5) mm and 0.60 (0.3-0.7) mm in the patients and the controls, respectively. Negative correlations were observed between Apelin-13 and age, ferritin, CRP, NLR and CIMT while positive correlations were found between calcium, ejection fraction (EF) and albumin. There was no correlation between apelin-13 and echocardiographic parameters except EF.

CONCLUSION: Apelin-13 levels tend to be lower in peritoneal dialysis patients, and may be important in the development of inflammation, endothelial dysfunction, and atherosclerosis.


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