1999, Cilt 8, Sayı 2, Sayfa(lar) 074-078
IS MICROALBUMINURIA A MARKER OF SYSTEMIC AND RENAL ENDOTHELIAL DEMAGE IN ESSENTIAL HYPERTENSION?
Saniye Şen1, Gülay Durmuş Altun2, Şükran Çiftçi2
1Trakya Üniversitesi Tıp Fakültesi Nefroloji Bilim Dalı, EDİRNE
2Trakya Üniversitesi Tıp Fakültesi Nükleer Tıp Anabilim Dalı, EDİRNE
Keywords: Essential hypertension, endothelium, microalbuminuria

Study was performed on 168 patients with essential hypertension (HT). Their SBP, DBP were 161,4±16 and 100,8±8 mmHg. Mean age was 47,6±9 years and HT duration was 46,8±4 months. 88 healthy subjects with mean age 46,4±9 years were included as a control. Endogenous creatinine clearance (GFR), proteinuria, urinary albumin excretion in minute (UAE) were measured. Plasma fibrinogen, vonWillebrand factor (vWF), serum lipoprotein, uric acid, electrolytes were measured. Proteinuria (P:0,019), UAE (P:0,000), fibrinogen (P:0,003), vWF (P:0,012), triglyceride (P: 0,001) and uric acid (P:0,000) values were higher in HT group. Microalbuminuria (MA) was observed %3,4 in control and %32 in HT group. There was %65 hypertensive retinopathy in patients. Our observations suggest that HT effects the systemic and renal endothelium at early stage.

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