2010, Cilt 19, Sayı 3, Sayfa(lar) 192-198
The Relationship between Endothelial Dysfunction and Pentraxin-3 Concentration in Chronic Kidney Disease
DOI 10.5262/tndt.2010.1003.07
Elvan ŞAHİN1, Fatih BULUCU1, Murat KARAMAN1, Ahmet Seyid AY1, Mutlu SAĞLAM3, Erdinç ÇAKIR4, Mahmut İlker YILMAZ2
1Gülhane Askeri Tıp Akademisi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye
2Gülhane Askeri Tıp Akademisi, Nefroloji Bilim Dalı, Ankara, Türkiye
3Gülhane Askeri Tıp Akademisi, Radyoloji Anabilim Dalı, Ankara, Türkiye
4Gülhane Askeri Tıp Akademisi, Biyokimya Anabilim Dalı, Ankara, Türkiye
Keywords: Endothelial dysfunction, Pentraxin-3, Chronic kidney disease

AIM: Cardiovascular diseases are the leading cause of morbidity and mortality in chronic kidney disease (CKD). Inflammation and endothelial dysfunction contribute to the development of cardiovascular disease in CKD. Pentraxin-3 (PTX-3), a new candidate marker for inflammation is expressed in a variety of cell types. We aimed to investigate the relation between plasma PTX-3, serum hs-CRP levels and endothelial dysfunction in CKD.

MATERIAL and METHODS: One hundred and twenty-five patients with CKD were studied. Patients were divided into 5 groups according to their glomerular filtration rate (GFR) as assessed by K/DOQI guidelines. Twenty-five healthy subjects were studied as controls. Venous samples were obtained from all subjects for PTX-3 and hs-CRP levels in addition to detailed metabolic panel. Endothelial dysfunction was assessed from all subjects by flow-mediated dilatation (FMD).

RESULTS: FMD levels were significantly decreased in all stages with the higher the stage of CKD, the lower the levels of FMD. Plasma PTX-3 levels of the stage 1-2-3 CKD group were similar to those of the controls, while other groups had significantly higher values (p<0.001). Additionally, hs-CRP levels were significantly increased in all stages of CKD. There was a significant positive correlation between FMD and GFR(r=0.762, p<0.001). There was also a significant negative correlation between FMD and PTX-3 (r=-0.414, p<0.001) as well as between FMD and hs-CRP (r=-0.546, p<0.001).

CONCLUSION: The results suggest that both plasma PTX-3 and hs-CRP levels are associated with endothelial dysfunction in CKD patients.


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